"Recombinant BCG Reporter Strains for Rapid Assessment of Anti-Mycobacterial Activity In Vivo."

According to an abstract presented by the authors to the Molecular Mechanisms in Tuberculosis Keystone Symposium, held February 19-25, 1995, in Tamarron, Colorado, "Methods for evaluating the antimicrobial activity of compounds on M. tuberculosis in the intracellular or in vivo environments are extremely arduous involving laborious agar plate colony forming unit (CFU) determinations and long incubations. Recent use of recombinant mycobacterial reporter strains expressing firefly luciferase has led to rapid in vitro drug susceptibility testing but the use of mycobacterial reporter strains has not been investigated in macrophages or animals. We constructed a variety of integrative...

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