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Anti-Cholesterol Vaccine Poised to Enter Human Trials

Published in Vaccine Weekly, April 17th, 1995

The admonition "Know your cholesterol number" may soon change to "Know your cholesterol antibody number" if clinical trials establish the efficacy of a new anti-cholesterol vaccine.

Although German researchers discovered in 1925 that cholesterol can be an immunogenic molecule, it was not until 1989 that normal human sera were found to contain various amounts of naturally occurring IgM and IgG antibodies to cholesterol.

"If you look at antibodies to cholesterol in healthy humans, many individuals have relatively high titers," reported Carol A. Nacy, senior vice president for research at EntreMed Inc., Rockville, Maryland, at the Third Annual Vaccines:...

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