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A New Target for Anti-HIV Strategies

Published in Vaccine Weekly, April 24th, 1995

A unique regulatory protein may be the Achilles heel of HIV, a series of new studies suggests.

Several separate laboratories are racing to develop novel drugs, vaccines and gene therapies that take advantage of these findings.

The new research shows that the protein, viral protein R (Vpr), may be far more important in HIV infectivity and pathogenesis than previously had been thought. If Vpr is indeed essential for HIV to cause AIDS, it will be an attractive target for intervention: unlike the viral proteins targeted by current AIDS therapies and HIV vaccines, Vpr is one of the most highly conserved HIV-1 proteins.

Vpr is the...

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