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Oral Vaccines - TB

"Oral Administration of BCG Induces Distinct Th1 and Th2 Responses in Systemic and Mucosal Lymphoid Tissues."

Published in Vaccine Weekly, April 24th, 1995

According to an abstract submitted by the authors to the Annual Meeting of Professional Research Scientists entitled Experimental Biology 95, held April 9-13, 1995, in Atlanta, Georgia, "Th1 type cell mediated immunity plays a major role in the protection against infection with Mycobacterium upon systemic challenge. However, Th1 and Th2 type immune responses induced by oral immunization with BCG are still not well characterized. In this study, mice were orally immunized with BCG for three consecutive days (109/mouse). CD4+ T cells were isolated from Peyer's patch (PP) and spleen (SP) of these immunized mice and from nonimmunized controls and then cultured...

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