HBV/Vaccine - Vaccine Development
"Derivation of Vaccines from Mimotopes - Immunologic Properties of Human Hepatitis B Virus Surface Antigen Mimotopes Displayed on Filamentous Phage."
Published in Vaccine Weekly, May 1st, 1995
According to the authors' abstract of an article published in Journal of Immunology, "We have previously reported the identification, using human immune sera, of mimotopes of human hepatitis B virus surface Ag (HBsAg) displayed on filamentous phage. To test if these mimotopes could be useful in developing a vaccine against the human hepatitis B virus (HBV), we have compared the humoral immune response of animals immunized either with a recombinant HBsAg vaccine, or with mimotopes. Immunogens were prepared by fusing the mimotopes on different carrier molecules (phage coat protein pill and pVIII, recombinant human H ferritin, HBV core peptide) and by synthesizing multiple antigenic...
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Source: Vaccine Weekly (1995-05-01)
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