Haemophilus Influenzae - Vaccine Comparison
"Functional Differences in Idiotypically Defined IgG1 Anti-Polysaccharide Antibodies Elicited by Vaccination with Haemophilus influenzae Type B Polysaccharide-Protein Conjugates."
Published in Vaccine Weekly, May 15th, 1995
According to the authors' abstract of an article published in Journal of Immunology, "We investigated the relationship between the form of the Haemophilus influenzae type B (Hib) polysaccharide (PS)-protein conjugate vaccine, Id expression, and Ab quality. Two post-vaccination pools were prepared from sera of infants vaccinated with either Hib PS oligomers coupled to CRM(197), a mutant diphtheria toxin (HbOC), or with higher m.w. Hib PS coupled to an outer membrane protein complex of Neisseria meningitidis group B (Hib-OMP). The mean anti-Hib PS Ab avidity of the serum pool from the infants vaccinated with HbOC was threefold higher than that of the pool from infants...
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Source: Vaccine Weekly (1995-05-15)
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