Published in Vaccine Weekly, May 22nd, 1995
Hepatitis B virus (HBV) infection is endemic in the Sahel area of west Africa, where there are high rates of hepatocellular carcinoma associated with chronic carriage of the virus. Transmission patterns of HBV infection differ between Africa and Asia. In Asia, perinatal transmission from mothers positive for HBV e antigen is more important, so early vaccination and, ideally, passive immunization are required for control. In Africa, chronic carriage of HBV is common in children and sibling-to-sibling transmission, which is easier to...
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