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Immunology

HIV-Specific CTL Patterns Suggest Vaccine Strategies

Published in Vaccine Weekly, May 29th, 1995

Different patterns of HIV-specific cytotoxic T-lymphocyte response can be seen after primary infection with HIV, suggesting potential vaccine strategies.

High levels of viremia during primary HIV infection have not been correlated with any clinically detected acute syndrome, but the virus titer declines significantly over the weeks following infection.

The mechanism by which viral antigen is cleared from the blood has not been fully elucidated, but an HIV-specific immune response is probably involved.

"Strong antibody responses to Env (gp160) and Gag (p24) proteins develop rapidly about one month after the onset of symptoms, at...

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