Immunology

Concurrent TIG and Td Administration Affects Response

Published in Vaccine Weekly, June 12th, 1995

Concurrent administration of tetanus immune globulin (TIG) and tetanus-diptheria (Td) vaccine interferes with the immune response to tetanus toxoid in subjects with low prevaccination antibody titers, according to a report from manufacturer SmithKline Beecham Pharmaceuticals.

In the management of wounds, adults are sometimes given Td vaccine dose plus TIG. In this study researcher Rafael Dal-Re and colleagues investigated whether the simultaneous administration of TIG and Td vaccine could interfere with the immune response to the latter in adult populations ("Does Tetanus Immune Globulin Interfere With the Administration of Tetanus-Diphtheria Vaccine' A Comparative...

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Source: Vaccine Weekly (1995-06-12)

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