"Neutralizing Antibodies against HIV-1 from Combinatorial Phage Display Libraries."

According to an abstract submitted by the authors to the 4th International Conference on Human Antibodies and Hybridomas, held April 26-28, 1995, in Amsterdam, The Netherlands, "Combinatorial phage display libraries were prepared from long-term HIV-1 seropositive survivors (>12 years). In initial experiments, monomeric HIV-1 envelope subunits were used for enrichment and screening of clones. Selection for potency and strain cross-reactivity was achieved through experimental design. Library donors were US males, presumably infected with a clade B strain of HIV-1, whereas the antigen for affinity selection was recombinant gp120 IIIB, thereby favoring selection of cross-reactive...

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