"Potency of Various Human Monoclonal Antibodies in Neutralization of HIV-1 Primary Isolates and Lab Strains."

According to an abstract submitted by the authors to the 4th International Conference on Human Antibodies and Hybridomas, held April 26-28, 1995, in Amsterdam, The Netherlands, "The envelope protein of HIV-1 is known to possess at least five regions which induce neutralizing antibodies in humans during infection. Monoclonal antibodies (MAbs) against three neutralizing epitopes V2, V3 and the CD4^- binding domain (CD4bd), were generated from lymphocytes derived from HIV-1 infected subjects by EBV transformation followed by fusion with a heteromyeloma. All MAbs were purified by Protein A chromatography and tested in neutralization assays against 10 primary isolates and 3...

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