"Lymphocytic 2',5'-Oligoadenylate Synthetase Activity Increases Prior to the Appearance of Neutralizing Antibodies and Immunoglobulin M and Immunoglobulin G Antibodies after Primary and Secondary Imm

According to the authors' abstract of an article published in Clinical and Diagnostic Laboratory Immunology, "Primary and secondary immunizations with live, attenuated yellow fever virus vaccine (17D strain) were performed in order to study the course of appearance of virus-neutralizing antibodies and immunoglobulin M (IgM) and IgG antibodies directed against the virus and the interferon-dependent enzyme 2',5'-oligoadenylate synthetase (2',5' AS) activity, determined in homogenates of peripheral B and T lymphocytes. From cellular ATP, this enzyme generates 2',5'-oligoadenylates which mediate degradation of viral mRNA by stimulation of a latent RNase. By day 4 after the first...

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