HIV Vaccine
"Prior Infection with a Nonpathogenic Chimeric Simian-Human Immunodeficiency Virus Does Not Efficiently Protect Macaques Against Challenge with Simian Immunodeficiency Virus."
Published in Vaccine Weekly, July 24th, 1995
According to the authors' abstract of an article published in Journal of Virology, "Prior infection with a nef-deleted simian immunodeficiency virus (SIV) protects macaques not only against a homologous pathogenic SIV challenge but also against challenge with a chimeric SIV expressing a human immunodeficiency virus type 1 env gene (SHIV). Since this SHIV is itself nonpathogenic, we sought to explore the use of a nonpathogenic SHIV as a live, attenuated AIDS virus vaccine. Four cynomolgus monkeys infected for greater than 600 days with a chimeric virus composed of SIVmac 239 expressing the human immunodeficiency virus type 1 HXBc2 env, tat, and rev genes were challenged intravenously with...
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Source: Vaccine Weekly (1995-07-24)
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