Vaccine Carriers
"Human Peripheral Blood CD4+ and CD8+ T Cells Express Th1-Like Cytokine mRNA and Proteins Following In Vitro Stimulation with Heat-Inactivated
Published in Vaccine Weekly, August 7th, 1995
According to the authors' abstract of an article published in Infection and Immunity, "Defining the pattern of lymphokine production associated with Brucella abortus is critical for advancing the development of B. abortus as a vaccine carrier. In the present study we investigated the ability of heat-inactivated B. abortus or lipopolysaccharide from B. abortus to induce lymphokine production from purified human T cells in vitro. Gamma interferon (IFN-gamma), interleukin-2 (IL-2), IL-4, and IL-5 induction was assayed by mRNA-specific PCR and by enzyme-linked immunosorbent assay and bioassay for protein production. Following depletion of monocytes and B cells,...
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Source: Vaccine Weekly (1995-08-07)
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