Vaccine Carriers
"Influence of Preimmunization with Tetanus Toxoid on Immune Responses to Tetanus Toxin Fragment C-Guest Antigen Fusions in a Salmonella vaccine Carrier."
Published in Vaccine Weekly, August 7th, 1995
According to the authors' abstract of an article published in Infection and Immunity, "We have previously described a new system for the delivery of recombinant antigens in live Salmonella vaccines as genetic fusions to the C terminus of fragment C of tetanus toxin (TetC) driven by the anaerobically inducible nirB promoter. It has been reported that preimmunization with tetanus toxoid (TT) can suppress the antibody response to peptides chemically coupled to TT (epitope-specific suppression) in both animals and humans, which could interfere with efficacy of the Salmonella-TetC delivery system. We report that preimmunization of BALB/c mice with TT in alum did not suppress the...
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Source: Vaccine Weekly (1995-08-07)
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