Biochemical Research

MHC Antigens and Heat Shock Proteins Linked in M. tb

Published in Vaccine Weekly, August 14th, 1995

A study examining the sequence and structural homologies between Mycobacterium tuberculosis chaperonin 10 and the MHC class I/II peptide binding cleft, suggests that MHC antigens and heat shock proteins (hsp) are evolutionarily linked.

The sequence related chaperonin 10 (cpn10, hsp 10 or 10kDa antigens) class of proteins mediate the folding of either newly synthesized proteins or proteins that following cellular stress have undergone denaturation. In addition to their chaperonin activity several cpn10s, such as M. tuberculosis and M. leprae cpn10s, are among the most potent stimulators of the immune system known. Since infectious microorganisms...

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Source: Vaccine Weekly (1995-08-14)

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