Immunology

Low Dose SIV Not Protective Against High-Dose Challenge

Published in Vaccine Weekly, August 14th, 1995

Rhesus macaques infected silently by low-dose exposure to infectious simian immunodeficiency virus (SIV) generated a virus-specific cellular immune response, but were not protected against high-dose SIV challenge.

Rhesus macaques develop an AIDS-like disease after infection with SIV. This SIV-macaque model is most reliable and widely use for AIDS pathogenesis and vaccine studies. Several researchers have successfully prevented the experimental SIV infection of macaques with candidate vaccines, but any clear correlation between the induction of humoral or cell-mediated immunity (CMI) and protection against an experimental infection has not been elucidated.

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Source: Vaccine Weekly (1995-08-14)

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