Published in Vaccine Weekly, September 4th, 1995
Live microbial vectors that actively multiply at mucosal surfaces are more efficient than killed vectors at stimulating a secretory response to a recombinant antigen, but in most cases these live antigen-delivery vectors comprise bacteria or viruses that are normally mammalian pathogens engineered to reduce their pathogenicity yet maintain certain invasive/adherence qualities to induce an immune response.
In an attempt to circumvent some of the safety and environmental issues inherent in the wide-scale dissemination of...
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