Vaccine Development

Commensal Bacteria May Offer Vaccine Delivery

Published in Vaccine Weekly, September 4th, 1995

Recombinant gram-positive commensal bacteria may be a safe and effective way of inducing local and systemic immune response.

Live microbial vectors that actively multiply at mucosal surfaces are more efficient than killed vectors at stimulating a secretory response to a recombinant antigen, but in most cases these live antigen-delivery vectors comprise bacteria or viruses that are normally mammalian pathogens engineered to reduce their pathogenicity yet maintain certain invasive/adherence qualities to induce an immune response.

In an attempt to circumvent some of the safety and environmental issues inherent in the wide-scale dissemination of...

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Source: Vaccine Weekly (1995-09-04)

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