"Long-Term Cytotoxic T Lymphocyte Memory in Local and Distant Mucosal Sites Following Intranasal Immunization with Recombinant Adenovirus."

According to an abstract submitted by the authors to the International Symposium on Clinical Immunology, held July 20-23, 1995, in San Francisco, California, "Here we examined the mucosal and systemic memory responses of virus-specific CTL following mucosal (i.n.) or systemic (i.p.) immunization with recombinant adenovirus capable of expressing herpes simplex virus (HSV) glycoprotein B (AdgB8). In order to compare mucosal memory CTL responses following AdgB8 immunization, mice were challenged i.n. or ivag with HSV-2 and the generation and precursor frequency of virus-specific CTL (CTLp) determined. Mice immunized i.n. generated a memory CTL response with high CTLp to HSV-2 in the...

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