Cancer Vaccines
"Construction, Purification, and Functional Incorporation on Tumor Cells of Glycolipid-Anchored Human B7-1 (CD80)."
Published in Vaccine Weekly, September 25th, 1995
According to the authors' abstract of an article published in Proceedings of the National Academy of Sciences of the United States of America, "To generate a potent cell-mediated immune response, at least two signals are required by T cells. One is engagement of the T-cell receptor with peptide-bearing major histocompatibility complex molecules. The other signal can be delivered by various molecules on the antigen-presenting cell, such as B7-1 (CD80). Many tumor cells escape immune recognition by failing to express these costimulatory molecules. Transfection of the B7 gene into some murine tumor cells allows for immune recognition and subsequent rejection of the parental tumor. We...
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Source: Vaccine Weekly (1995-09-25)
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