"Vaccine-Induced Virus-Neutralizing Antibodies and Cytotoxic T Cells Do Not Protect Macaques from Experimental Infection with Simian Immunodeficiency Virus SIVmac32H (J5)."

According to the authors' abstract of an article published in Journal of Virology, "To gain further insight into the ability of subunit vaccines to protect monkeys from experimental infection with simian immunodeficiency virus (SIV), two groups of cynomolgus macaques were immunized with either recombinant SIVmac32H-derived envelope glycoproteins (Env) incorporated into immune-stimulating complexes (iscoms) (group A) or with these SIV Env iscoms in combination with p27(gag) iscoms and three Nef lipopeptides (group B). Four monkeys immunized with recombinant feline immunodeficiency virus Env iscoms served as controls (group C). Animals were immunized intramuscularly at weeks 0, 4, 10, and...

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