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CMV Subunit Vaccine Could Reduce Infant Mortality and Morbidity

Published in Vaccine Weekly, November 20th, 1995

Vaccines could prevent congenital cytomegalovirus (CMV) disease - a major public health problem - but there are several obstacles to their clinical development.

Each year in the U.S. there are 40,000 cases of congenital CMV infection. Although most cases are asymptomatic, in some 7 percent of infants there are serious consequences, with common manifestations of jaundice, petechiae, hepatosplenomegaly, low birth weight, and microcephaly.

But there are severe long-term consequences even for children originally asymptomatic, said vaccine researcher Rae Lyn Burke of Chiron Corp., Emeryville, California.

"There is roughly a 10 percent...

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Source: Vaccine Weekly (1995-11-20)

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