"Cross-Clade Neutralization of Primary Isolates of Human Immunodeficiency Virus Type 1 by Human Monoclonal Antibodies and Tetrameric CD4^-IgG."

According to the authors' abstract of an article published in Journal of Virology, "We have tested three human monoclonal antibodies (MAbs) IgG1b12 2G12, and 2F5) to the envelope glycoproteins of human immunodeficiency virus type 1 (HIV-1), and a tetrameric CD4^-IgG molecule (CD4^-IgG2), for the ability to neutralize primary HIV-1 isolates from the genetic clades A through F and from group O. Each of the reagents broadly and potently neutralized B-clade isolates. The 2F5 MAb and the CD4^-IgG2 molecule also neutralized strains from outside the B clade, with the same breadth and potency that they showed against B clade strains. The other two MAbs were able to...

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