Pathogenesis

Virulence Factors Key To Pulmonary TB

Published in Vaccine Weekly, December 4th, 1995

Virulence factors appear to provide mycobacteria with a capacity to survive in the lung and cause progressive disease, in spite of the state of host immunity, according to a report from New York's Trudeau Institute.

This research may further the search for a more efficacious tuberculosis vaccine.

In earlier research Pamela L. Dunn and Robert North confirmed that virulent strains of Mycobacterium tuberculosis cause progressive infection in the lungs but not in other organs. Murine studies showed with one virulent strain that infection in the lungs progressed despite the generation of CD4⁺ T-cell mediated immunity that was capable of...

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Source: Vaccine Weekly (1995-12-04)

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