Published in Vaccine Weekly, February 19th, 1996
Recent findings from the laboratory of Robert Gallo showed that the C-C chemokines RANTES, MIP-1(alpha), and MIP-1(beta) have potent anti-HIV activity.
It was suggested that these T-cell-produced substances could be the long-sought suppressive factor produced by the CD8+ cells of long-term non-progressors.
But an Italian research group now warns that attempts to manipulate chemokines may backfire. Guido Poli and colleagues of the San Raffaele Scientific Institute, Milan, Italy, have found that some chemokines actually...
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