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Measles

"Secondary Failure Rates of Measles Vaccines: A Metaanalysis of Published Studies."

Published in Vaccine Weekly, March 4th, 1996

According to the authors' abstract of an article published in Pediatric Infectious Disease Journal, "Background: Recent measles outbreaks in highly vaccinated populations have highlighted the role of vaccine failure as a barrier to the elimination of measles. We sought to estimate the rate of secondary failure (clinical measles after vaccine-induced seroconversion) of measles vaccines using metaanalysis. Methods: We identified 1411 studies of which 125 were relevant. From these we found 10 original studies of healthy subjects with sufficient details to calculate a pooled secondary failure rate. We performed a test for homogeneity before any pooling. Results: ...

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