Cancer Vaccines
Systemic IL-12 Boosts Effect of IL-2 Producing Cancer Vaccine
Published in Vaccine Weekly, March 11th, 1996
When genes for cytokines, like IL-12 and IL-2, are transduced in tumor cells they stimulate an efficient antitumor reaction which involves both nonspecific and specific immune mechanisms that impairs the oncogenicity of the engineered cells. When used as a vaccine, these cells are capable of eliciting an immune memory which inhibits subsequent tumor challenge.
Unfortunately, when tackling established tumors, the effect of cytokine tumor vaccines lacks enough punch to cure a well-established cancer. However, of all the...
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Source: Vaccine Weekly (1996-03-11)
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