Vaccine Development (HSV-2)
Nucleic Acid Vaccine Protects Mice from Herpes Simplex Virus-2
Published in Vaccine Weekly, March 11th, 1996
The gD2 envelope glycoprotein of HSV-2 has an important role in the attachment and penetration of the virus into the host cells. It has been shown that serum antibodies against gD develop naturally in all patients infected with HSV-2. T cells that specifically respond to gD have also been isolated from HSV infected mice.
Monoclonal antibodies directed against HSV gD have been shown to provide passive immunity against the disease in animal models. HSV prophylactic subunit vaccines containing gD2 have been...
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Source: Vaccine Weekly (1996-03-11)
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