Cancer Vaccines
"Development and Characterization of an Interleukin-2-Transduced Human Ovarian Carcinoma Tumor Vaccine not Expressing Major Histocompatibility Complex Molecules."
Published in Vaccine Weekly, April 1st, 1996
According to the authors' abstract of an article published in American Journal of Obstetrics and Gynecology, "Objective: We initiated studies to develop cytokine-secreting human ovarian carcinoma cells for the purpose of using these cells as vaccines for the treatment of advanced epithelial ovarian cancer. Study Design: A human ovarian carcinoma cell line (UCI-107) was genetically engineered to secrete the cytokine interleukin-2 by retroviral-mediated gene transduction. Results: One clone, termed UCI-107A IL-2 AS, constitutively secreted high levels of interleukin-2 (i.e., 2000 to 2300 pg/ml/105 cells per 48 hours) for >55 passages and 8 months of...
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Source: Vaccine Weekly (1996-04-01)
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