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Flu Immunization in HIV Children Does Not Enhance Replication

Published in Vaccine Weekly, April 8th, 1996

The effect of influenza vaccination on HIV positive children has been unclear.

Some researchers have suggested that vaccination-mediated immune stimulation might activate T cells and enhance HIV replication. This prompted Dr. Octavio Ramilo and colleagues at the University of Texas Southwestern Medical Center in Dallas to investigate the effect of influenza immunization on T-cell activation and HIV burden in children, (Pediatr Infect Dis J 1996;15:197-203).

Ramilo observed significant increases in HIV viral load in the blood samples of five of 16 children after administration of influenza vaccine. However, HIV burden increases were transient and...

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