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Conference Coverage (CHI Vaccines)

Novel Adjuvant Induces Cellular Immune Responses

Published in Vaccine Weekly, April 22nd, 1996

An antigen derived from a pathogenic protozoa improves the efficacy of experimental antitumor vaccines.

The antigen has the extraordinary ability to stimulate T-helper type 1 (Th1)-mediated cellular immune responses in the absence of Th2-mediated antibody responses.

Because of this immunological profile, the antigen could be used as an adjuvant for therapeutic vaccines in which cytotoxic lymphocyte (CTL) responses are desired. This is precisely the goal of most therapeutic cancer vaccine strategies.

The antigen, dubbed LeIF, is derived from Leishmania protozoa, said Kenneth H. Grabstein, vice president of Coriza...

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