Immunotherapy (Cancer)
"Therapy of Murine Tumors with p53 Wild Type Sequence Peptide-Based Vaccine."
Published in Vaccine Weekly, April 29th, 1996
According to an abstract submitted by the authors to the 87th Annual Meeting of the American Association for Cancer Research, held April 20-24, 1996, in Washington, D.C., "As a result of p53 overexpression in tumors, peptides derived from non-mutated portions of the molecule have the potential of being targets for cellular immunotherapy. BALB/cJ mice were immunized with bone marrow-derived dendritic cells (generated with GM-CSF/IL-4), and pulsed with H-2Kd-binding p53 wild type sequence peptide(232-240). This vaccine induced peptide-specific CTL which reacted against 3 of 5 BALB/c sarcomas tested, including CMS4, and rejection of CMS-1 sarcoma in vaccination and therapy (day 7)...
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Source: Vaccine Weekly (1996-04-29)
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