Conference Coverage (AACR)

Cancer Immunotherapy with Bacterial Superantigen Staphylococcal Enterotoxin A

Published in Vaccine Weekly, May 6th, 1996

An immunoconjugate consisting of the bacterial superantigen Staphylococcal enterotoxin A (SEA) and a colon carcinoma monoclonal antibody induces cell surface leukocyte activation markers in colon carcinoma patients.

SEA is a potent T-cell specific mitogen that activates >10 percent of T cells following crosslinking of TCR V(beta) regions with MHC class II molecules. By combining SEA with the Fab-fragment of C242 monoclonal antibody which recognizes Le^A, a glycoprotein over-expressed in colon/pancreatic carcinomas, a recombinant E. coli-derived fusion protein labelled LS4565 was created.

Katherine Alpaugh, of the Fox Chase Cancer...

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Source: Vaccine Weekly (1996-05-06)

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