Published in Vaccine Weekly, May 6th, 1996
SEA is a potent T-cell specific mitogen that activates >10 percent of T cells following crosslinking of TCR V(beta) regions with MHC class II molecules. By combining SEA with the Fab-fragment of C242 monoclonal antibody which recognizes LeA, a glycoprotein over-expressed in colon/pancreatic carcinomas, a recombinant E. coli-derived fusion protein labelled LS4565 was created.
Katherine Alpaugh, of the Fox Chase Cancer...
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