TB Vaccines

Internal Membrane Proteins Promising Vaccine Candidates

Published in Vaccine Weekly, May 20th, 1996

Internal membrane proteins may be promising vaccine candidates for tuberculosis, according to a report from India.

Growing evidence suggests that membrane proteins from a variety of pathogens could be highly immunogenic.

"Immunogenicity of membrane proteins, especially the 'integral' ones, has been attributed to their inherent hydrophobicity which could be accentuated by a naturally occurring lipid modification," researcher J. Mehrotra and colleagues wrote ("Serological Distinction of Integral Plasma Membrane Proteins as a Class of Mycobacterial Antigens and Their Relevance for Human T Cell Activation," Clinical and Experimental Immunology,...

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Source: Vaccine Weekly (1996-05-20)

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