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Combination Gene Transfer Possible in Human Melanoma Cells

Published in Vaccine Weekly, May 27th, 1996

Dual gene transfection within the same cell allows for the expression of a co-stimulatory molecule and the necessary presenting antigen.

Because it has been shown that T-cell destruction of human melanomas will not occur if the melanoma tumor lacks the necessary co-stimulatory molecule, lacks sufficient MHC expression, and lacks the necessary melanoma tumor antigen, Mark. R. Albertini et al. explored the possibility of dual transfection of melanoma cells to facilitate T-cell destruction and presented the results at the 87th Annual Meeting of the American Association for Cancer Research, held April 20-24, 1996, in Washington, DC.

"The importance of...

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