Vaccine Development (Salmonella)
"Two New Virulence Genes in Salmonella typhimurium, a Possible Tool for Living Vaccine."
Published in Vaccine Weekly, July 8th, 1996
According to an abstract submitted by the authors to the 4th International Conference on the Prevention of Infection, held May 6-7, 1996, in Nice, France, "Two new virulence genes, orf34 and orf57, located at 23 min on the S. typhimurium chromosome were identified and characterized. Insertional mutation of orf34 and orf57 reduced by 3 logs the LD50 of the highly virulent isogenic wild type (WT) strain after peritoneal challenge in mice. Mice surviving this challenge were protected from a 2nd challenge with WT at high inoculum. In contrast to the WT, orf34 and orf57 mutants failed to propagate in macrophages. orf34 and orf57...
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Source: Vaccine Weekly (1996-07-08)
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