Vectors (Development)

Stripped Vector Transfects Larger DNA Sequences/Bypasses Immune Response

Published in Vaccine Weekly, July 15th, 1996

A stripped down adenoviral vector has been developed in which the expression of viral proteins has been decreased and DNA insert capacity increased.

Problems with first generation adenoviral vectors include their limited foreign DNA carrying capacity as well as problems associated with the host immune response which is triggered by the production of viral proteins. This host immune response is believed to be ultimately responsible for the limited expression of the therapeutic gene.

Stefan Kochanek et al. constructed a new adenoviral vector and tested its efficacy in a murine model of muscular dystrophy ("A New Adenoviral Vector: Replacement of All...

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Source: Vaccine Weekly (1996-07-15)

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