Pathogenesis

30/32 kDa Localized to Phagosomal Space/Mycobacterial Cell Wall

Published in Vaccine Weekly, August 19th, 1996

The 30/32 kilodalton complex of the Mycobacterium tuberculosis proteins is expressed in human monocytes and is localized to the phagosomal space and the mycobacterial cell wall, according to a report from the University of California.

These findings involving the pathogenesis of Mycobacterium tuberculosis may have implications for the development of protein-based subunit vaccines.

"These analyses fill important gaps in our knowledge of this critical protein complex of M. tuberculosis and, at the same time, raise new and fundamental questions regarding regulatory mechanisms that control coordinate expression of the proteins at a...

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Source: Vaccine Weekly (1996-08-19)

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