HIV Vaccines
"TCA3 and Interleukin-12 as Cytokine Adjuvants on Candidate HIV-1 DNA Vaccine."
Published in Vaccine Weekly, September 9th, 1996
According to an abstract submitted by the authors to the 11th International Conference on AIDS, held July 7-12, 1996, in Vancouver, British Columbia, "Objective: To determine whether TCA3 and interleukin (IL) -12 expression plasmids have adjuvant activities on HIV-1 specific cell-mediated immunity (CMI) induced by our candidate HIV-1 DNA vaccine. Methods: TCA3 or IL-12 expression plasmid was coinoculated with HIV-1IIIB gp160 expression plasmid (hereafter DNA vaccine) into mouse gastrocnemius muscles. Two weeks after inoculation, Delayed type hypersensitivity (DTH) was assayed by using footpad swelling response. Three weeks after inoculation, cytotoxic T...
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Source: Vaccine Weekly (1996-09-09)
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