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Genentech HIV Vaccine Safe, But Three Thai Subjects Get HIV

Published in Vaccine Weekly, September 23rd, 1996

Three of the 33 subjects in Thailand's Phase II trial of the Genentech HIV vaccine became infected with HIV.

None of the infections were caused by the vaccine, which contains only the gp120 envelope protein of HIV-1 clade B strain MN. All of the infections were caused by HIV-1 strains belonging to clade E.

The trial was not designed to test the efficacy of the vaccine, and recipients of the vaccine were not expected to become immune to all strains of HIV.

"Two of the volunteers were infected after [receiving] the second dose and one was infected after the third dose," said Sricharoen Migasena of the Mahidol University Faculty of...

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