"Augmentation of Antitumor Immunity with Bacterial Superantigen, Staphylococcal Enterotoxin B-Bound Tumor Cells."

According to the authors' abstract of an article published in Cancer Research, "We have examined the effectiveness of a bacterial superantigen, staphylococcal enterotoxin B (SEB)-coupled tumor cells, to induce antitumor activity. SEB was chemically conjugated to tumor cells using a heterobifunctional cross-linking agent acting through NH2 and SH groups. V pst T cells were activated and increased in number after the culture with SEB-bound Meth A cells. The cultured T cells exhibited an antitumor activity in the Winn assay. Interleukin 2 (IL-2) receptor alpha+ (IL-2R⁺) V beta 8⁺ T cells but not IL-2R⁺ V beta 6⁺ T cells increased in number in...

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