"Immunization Against Malaria Using a Recombinant Protein Formulated in Adjuvants Developed for Human Use."

According to an abstract submitted by the authors to the 7th Malaria Meeting of the British Society for Parasitology, held September 18-20, 1995, in London, United Kingdom, "Mice immunized with a recombinant protein encompassing the two epidermal-growth-factor (EGF)-like modules of Plasmodium yoelii merozoite surface protein-l (MSP-I) are known to be protected against challenge with the lethal P. yoelii YM strain. This protection is dependent on both EGF-like modules being present in tandem, and the protein being in a native conformation. The mechanism of this protection is not known but antibody appears to play an important part, particularly during the early stages of...

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