HIV Vaccines
"Chimeric Viruses Between SIVmac and Various HIV-1 Isolates Have Biological Properties That Are Similar to Those of the Parental HIV-1."
Published in Vaccine Weekly, November 25th, 1996
According to the authors' abstract of an article published in AIDS, "Objective: To examine the biological properties of HIV-1/SIVmac chimeric viruses from HIV-1 isolates that have different replication rates, cell tropisms and cytopathicities. Design and Methods: Four chimeric viruses with gag, pol, vif, vpx, nef and long terminal repeats of SIVmac and vpr, tat, rev, vpu and env of various HIV-1 isolates were constructed and compared in vitro. Cynomolgus monkeys were inoculated with two chimeras that were replicative in monkey peripheral blood mononuclear cells (PBMC). Results: The type-specific neutralization of the chimeras by monoclonal antibodies 0.5...
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Source: Vaccine Weekly (1996-11-25)
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