"Apical Membrane Antigen 1: A Potential Malaria-Vaccine Candidate."

According to an abstract submitted by the authors to the 7th Malaria Meeting of the British Society for Parasitology, held September 18-20, 1995, in London, United Kingdom, "The ectodomain of apical membrane antigen-1 in vitro protected immunized mice against challenge (AMA-1) expressed in Escherichia coli and refolded with the homologous DS strain of P. chabaudi adami but not with the heterologous 556KA strain. Because reduced and alkylated AMA-1 does not protect, the connectivities of the 16 conserved cysteine residues were examined. Mass spectrometry and N-terminal sequencing of tryptic fragments derived from the AMA-1 ectodomain secreted from BV-transfected insect cells...

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