Published in Vaccine Weekly, November 25th, 1996
Pgh-1 may serve as a drug transporter in a way similar to mammalian P-glycoprotein, said Stephan Ruetz, Mc Gill University, Montreal, Quebec, Canada, and colleagues ("The pfmdr1 Gene of Plasmodium falciparum Confers Cellular Resistance to Antimalarial Drugs in Yeast Cells," Proceedings of the National Academy of Science USA, 1996;93:9942-9947).
Their findings also suggested that sequence variants associated with drug resistance in pfmdr1 alleles act as loss of function mutations.
The precise role of the Plasmodium falciparum...
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