"Effect of Antigenic Drift of Influenza Virus Hemagglutinin on Humoral Immunity Generated by DNA Vaccination."

According to an abstract submitted by the authors to the 15th Annual Meeting of the American Society for Virology, held July 13-17, 1996, in Ontario, Canada, "Respiratory virus infections such as influenza continue to be leading causes of morbidity and mortality throughout the world. The increasing sophistication of DNA vaccines encoding foreign proteins represents a possible control of respiratory disease. However, there is the need for further understanding the mechanisms by which immunity is established. Our earlier studies have used the murine influenza virus model and intradermal gene-gun delivery of hemagglutinin (HA)-encoding naked DNA. Immunization was shown to be as...

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