"Induction of HIV Specific Cytotoxic T-Cell Responses by HIV Gag Particle Carrying Immunodominant Multiple V3 Loop of GP120."

According to an abstract submitted by the authors to the 15th Annual Meeting of the American Society for Virology, held July 13-17, 1996, in Ontario, Canada, "Efforts to develop a vaccine to prevent infection by human immunodeficiency virus (HIV) have focused on induction of neutralizing antibodies (Proc. Natl. Acad. Sci USA 89, 10527-10531, 1992). Cytotoxic T-lymphocyte (CTL) responses are another major immune defense mechanism required for recovery from many different virus infections. Since CTL epitope can be defined by short synthetic peptides, we used HIV gag particle as carriers for the three tandem copies of consensus V3 loop sequence (V3B) as well as V3 loop sequences from...

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