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HCV Gene Therapy

RAd May Be Useful for HCV Vaccine/Treatment

Published in Vaccine Weekly, March 10th, 1997

Replication-defective recombinant adenoviruses can efficiently express hepatitis C virus (HCV) proteins and are able to induce an in vivo cytotoxic T-cell response against a diversity of epitopes from HCV antigens, according to a European multicenter report.

"These vectors should be taken into consideration in the design of vaccines and also as a means to stimulate specific T-cell responses in chronic HCV carriers," Oscar Bruna-Romero and colleagues wrote ("Induction of Cytotoxic T-Cell Response Against HCV Structural Antigens Using a Defective Recombinant Adenovirus," Hepatology, February 1997;25(2):470-477).

HCV infection has a strong tendency to...

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