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Chagas Disease (Vaccine)

"Immunization of Mice Against Trypanosoma cruzi Using Salmonella typhimurium (AroA-) Expressing the Protein Core of GP72."

Published in Vaccine Weekly, March 17th, 1997

According to an abstract submitted by the authors to the 45th Annual Meeting of the American Society of Tropical Medicine and Hygiene, held December 1-5, 1996, in Baltimore, Maryland, "We have assessed the ability of an oral vaccine, consisting of Salmonella typhimurium (AroA-) expressing the protein core of gp72 of Trypanosoma cruzi, to protect mice against a contaminative challenge with infective parasites. A PCR-produced fragment encoding the protein core of gp72 was inserted into pGEX and pHS164. pHS164-gp72 propagated in S. typhimurium LB5000 (res-, met+) was used to transform S. typhimurium SL33-2. Mice were immunized with 4 oral...

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