Mucosal Immunization
"Mucosal Unresponsiveness to Aflatoxin B-1 is not Broken by Cholera Toxin."
Published in Vaccine Weekly, March 24th, 1997
According to the authors' abstract of an article published in Immunology and Cell Biology, "Rabbits immunized via chronically isolated ileal loops with aflatoxin B-1 (AFB) conjugated to porcine thyroglobulin (TG) mixed with the mucosal adjuvant cholera toxin (CT) produced very small mucosal antibody responses to AFB. Strong mucosal and systemic antibody responses to CT and TG were generated by this immunization protocol, suggesting that the observed unresponsiveness was specific to AFB. Parenteral immunization with AFB-TG produced strong serum IgG anti-AFB responses, indicating that the conjugate preparation was immunogenic and that the rabbits possess the requisite systemic B- and...
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Source: Vaccine Weekly (1997-03-24)
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